GnRH Receptor
Gonadotropin releasing hormone receptor; GNRHR
The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.
Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.
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GnRH Receptor Related Products (161)
Related Products (161)
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Antibodies (3)
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(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
0 ImagesCat. No.: HY-P4467CAS No.: 1642799-35-6Synonyms: (Des-Pyr1)-Leuprolide(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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[Lys8] LH-RH
![[Lys8] LH-RH](https://file.medchemexpress.com/product_pic/hy-p3663.gif "Click to View [Lys8] LH-RH Product Detail")
0 ImagesCat. No.: HY-P3663CAS No.: 35544-05-9[Lys8] LH-RH is a analogue of LH-RH. [Lys8] LH-RH stimulates LH and FSH release.
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Ozarelix
0 ImagesCat. No.: HY-16375CAS No.: 295350-45-7Synonyms: D-63153
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Azaline B
0 ImagesCat. No.: HY-P10472CAS No.: 134457-28-6Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception.
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(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
0 ImagesCat. No.: HY-P4577CAS No.: 1426173-74-1(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
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(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH
0 ImagesCat. No.: HY-P4441CAS No.: 134009-10-2(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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(D-Ser6,Azagly10)-LHRH
0 ImagesCat. No.: HY-P4570CAS No.: 65807-03-6(D-Ser6,Azagly10)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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(D-His(Bzl)6)-LHRH (1-7) free acid
0 ImagesCat. No.: HY-P10490CAS No.: 1926163-27-0(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide compound that is a derivative of luteinizing hormone-releasing hormone (LHRH). (D-His(Bzl)6)-LHRH (1-7) free acid enhances its stability and biological activity by introducing unnatural amino acid residues at specific positions of the LHRH molecule. This modification can improve the drug's performance in the body half-life, reducing the rate at which it is rapidly metabolized and cleared, thereby enhancing its efficacy in inhibiting cell proliferation.
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Org-30850
0 ImagesCat. No.: HY-P0037CAS No.: 136208-71-4Synonyms: Org 30850ANTOrg-30850 is a potent LHRH antagonist designed for treating hormone-dependent disorders. In animal studies, a single subcutaneous dose effectively inhibited ovulation in rats and significantly reduced testosterone levels in male rats for up to 48 hours post-administration. Daily doses of Org-30850 in female rats suppressed estrous cycles, decreased uterine and ovarian weights, and lowered estradiol and FSH serum levels. In male rats, prolonged treatment resulted in reversible reductions in gonadal function and testosterone levels, with almost complete recovery observed after cessation of treatment. Unlike comparable LHRH antagonists, Org-30850 exhibited minimal injection site irritation and no edematous reactions, suggesting a more favorable therapeutic profile.
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Degarelix-d7 TFA
0 ImagesCat. No.: HY-16168AS1Synonyms: FE 200486-d7 TFADegarelix-d7 TFA (FE 200486-d7 TFA) is the deuterium labeled Degarelix TFA. Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC50 = 3 nM). Degarelix acetate Degarelix acetate (FE 200486) is used for the research of prostate cancer.
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[D-Phe2,D-Ala6]-LH-RH
![[D-Phe2,D-Ala6]-LH-RH](https://file.medchemexpress.com/product_pic/hy-p3664.gif "Click to View [D-Phe2,D-Ala6]-LH-RH Product Detail")
0 ImagesCat. No.: HY-P3664CAS No.: 54784-44-0Synonyms: Wy 18185[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities.
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Kisspeptin 13
0 ImagesCat. No.: HY-P3641CAS No.: 374675-18-0Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
![[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide](https://file.medchemexpress.com/product_pic/hy-p3670.gif "Click to View [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide Product Detail")
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(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)
0 ImagesCat. No.: HY-P4432CAS No.: 88848-87-7(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that induces ovulation and/or spawning in farmed fish.
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(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH
0 ImagesCat. No.: HY-P4447CAS No.: 1926163-26-9(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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[D-Ala6]-LH-RH
![[D-Ala6]-LH-RH](https://file.medchemexpress.com/product_pic/hy-p3672.gif "Click to View [D-Ala6]-LH-RH Product Detail")
0 ImagesCat. No.: HY-P3672CAS No.: 51230-19-4[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist.
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Relugolix-d6
0 ImagesCat. No.: HY-16474SPurity: 98.02%Synonyms: TAK-385-d6Relugolix-d6 is deuterium labeled Relugolix. Relugolix (TAK-385)?is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.
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Degarelix-d7 TFA-1
0 ImagesCat. No.: HY-16168AS2Synonyms: FE 200486-d7 TFA-1Degarelix-d7 TFA-1 (FE 200486-d7 TFA-1) is the deuterium labeled Degarelix TFA. Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC50 = 3 nM). Degarelix acetate Degarelix acetate (FE 200486) is used for the research of prostate cancer.
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GnRH-R antagonist-2
0 ImagesCat. No.: HY-178418CAS No.: 1000819-21-5GnRH-R antagonist-2 (Compound 44c) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 43 and 88 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-2 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research.
